May 7, 2009
Did you know that there is a sensor in the nerve endings in the
carotid artery that rapidly lowers blood pressure when stimulated?
This discovery may one day allow people who are hypertensive to
lower their blood pressure by using a pacemaker-like device that
stimulates the nerve endings in the blood vessels.
In this edition of Life
Lines, we talk to Francois
Abboud, of the Carver College of Medicine at the
University of Iowa whose
research identified this sensor. We’ll also talk to him about his
recent research looking at the genes that regulate ion channels,
microscopic gates that move chemicals in and out of cells, and that
play a role in the signaling between the brain and the blood
vessels. In experiments with animals, Dr. Abboud and his colleagues
deleted one specific ion channel and found that the animals
developed high blood pressure. (Begins at 03:51)
We'll also talk to Ann M.
Schreihofer, of the Medical
College of Georgia, who focuses on the role the brain plays
in increasing sympathetic nervous activity, which contributes to
many forms of hypertension (high blood pressure). Among the
questions her research seeks to answer is why people who are obese
become hypertensive.
The Schreihofer laboratory has also been looking at sleep apnea and
whether it is possible to improve respiratory function as a way to
reduce the sympathetic activity that leads to obesity and
hypertension. (Begins at 09:43)
In the Buzz in Physiology
(begins at 1:24), we have studies on:
The photo in our logo is a neuron from the rostral ventral
lateral medulla of the brain stem and was provided by Dr.
Schreihofer.
Total running time: 16:45.
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