Episode 20: Celiac Research Update
Apr 6, 2009
Celiac Update. Celiac disease is an uncontrolled immune response
to wheat gluten and similar proteins of rye and barley. In those
who have celiac disease, gluten can damage the small intestine,
inhibit nutritional uptake and lead to malnutrition. Among the
symptoms are diarrhea, stomach pain, fatigue, weight loss and slow
growth. One study estimated that 1 in 133 people in the U.S.
population have celiac disease. Many people do not know they have
it, sometimes because there are no symptoms. Because celiac disease
has a genetic component, there can be a much higher prevalence of
the disease within families.
Three years ago, a group of Dutch researchers led by Frits Koning
of the Leiden University Medical Center published a study on an
enzyme that showed promise as a treatment for celiac disease. The
enzyme, prolyl endoprotease, or PEP, could quickly break down
gluten in the stomach before it ever reached the small intestine,
where it causes damage. In this episode, we ask Frits Koning to
update us on his research. (Begins at 2:45)
Total Time: 11:20
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